Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β.

Indeed, we found that Vps34 was elevated at 84 days after vector administration, with a strong trend ( p = 0.06) to be elevated at 24 days ( Fig. 3 D ).

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Finally, consistent with previous studies of ASB2 targets in different cell types ( 16 , 21 , 22 , 85 , 86 , 87 , 88 ), we found that WT ASB2β was associated with filamin A (Flna); however, this association did not quite reach significance with dSOCS ASB2β ( supplemental Table S3 ).

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