Genetically determined telomere length and multiple myeloma risk and outcome.

The IVW regression showed a highly significant association between the 11 SNPs used as genetic instruments of exposure and risk of developing MM (coeff = 1.175, 95% CI 0.61–1.75, P = 5.38 × 10 −5 ), whereas the MR-Egger regression showed a statistically non-significant association (coeff = 0.532, 95% CI −1.16 to 2.22, P = 0.538), although in line with IVW regression, with the intercept slightly, but not significantly, different from zero (intercept = 0.06, 95% CI −0.09 to 0.20, P = 0.428).

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The analyses between teloscore and OS of MM patients showed a trend between having longer gdTL and better MM survival, considering the quintile as a continuous variable for unweighted (HR = 0.93; 95%CI 0.85–0.99; P = 0.046) or weighted (HR = 0.93; 95% CI 0.86–0.99; P = 0.049) score, adjusted by DS staging system.

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