Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach.

Analysis of a group of 9 markers of the primed pluripotent state, by contrast, showed a clear trend towards higher expression in all three time points (Additional file 1 : Figure S3E-F), suggesting that differentiation of female cells with a double X-dosage is also delayed in embryos in vivo.

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As a consequence, most naive markers were not well detected in the data set we analyzed and a combined analysis of 9 naive factors revealed only a slight trend towards higher expression in female cells at E4.5 (Additional file 1 : Figure S3C-D).

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