Hormone receptor status influences the impact of body mass index and hyperglycemia on the risk of tumor relapse in early-stage HER2-positive breast cancer patients.

By contrast, in the HR+/HER2+ BC cohort we found no statistically significant association between BMI and RFS (hazard ratio 1.36; 95% CI: 0.61–3.07, p = 0.452), while hyperglycemia was associated with worse RFS at univariate analysis (hazard ratio 2.85; 95% CI: 1.02–8.00, p = 0.047), with a clear trend toward worse RFS also at multivariable analysis (hazard ratio 2.52; 95% CI: 0.89–7.1; p = 0.080) ( Figure 2 ; Table 4 ).

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