Cerebrospinal Fluid Neurofilament Light Chain (NfL) Predicts Disease Aggressiveness in Amyotrophic Lateral Sclerosis: An Application of the D50 Disease Progression Model.

Front Neurosci · 2021 · PMC8056017 · PMID 33889072

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.3370

boldest claim

The sentences

highly significantp < 0.001actually significant

We found highly significant differences in NfL concentrations between all three D50 subgroups ( p < 0.001), representing an increase of NfL levels with increasing disease aggressiveness.

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did not reach statistical significancep < 0.337not close (p > 0.1)

Patients in phase III/IV showed a similar tendency of negative correlation, but did not reach statistical significance, most likely due to the small sample size ( n = 7, p < 0.337, ρ = −0.429).

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