Programmed Death-1/Programmed Death-Ligand 1-Axis Blockade in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Stratified by Human Papillomavirus Status: A Systematic Review and Meta-Analysis.

Front Immunol · 2021 · PMC8058384 · PMID 33897693

Europe PMC DOI

hedged sentences

0.1200

closest p · 2.4× alpha

0.1200

boldest claim

The sentences

failed to reach significanceP = 0.12not close (p > 0.1)

We noticed that there was a higher ORR in HPV positive over HPV negative HNSCC patients undergoing anti-PD-1 therapy in our analysis; however, this difference failed to reach significance ( P = 0.12).

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showed a trendno p-value reported

( 25 ) both showed a trend towards significance for higher response rates in HPV positive vs.

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trend toward significanceno p-value reported

As more and higher-quality trial data emerges, this difference may also trend toward significance.

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a trend towards significanceno p-value reported

Data from two recent meta-analyses ( 24 , 25 ) suggest there is a trend towards significance favoring higher response rates in HPV positive vs.

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