Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.

The difference between participants with LRRK2 PD and those with idiopathic PD also did not reach statistical significance, but the magnitude and direction of the difference was similar to our prior work. 30 Our overall finding, that cognition was not worse in participants with LRRK2 / GBA PD than in those with only the LRRK2 variation, challenges cellular and clinical data suggesting convergent deleterious associations of dual LRRK2 and GBA variations.

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