Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats.

In a preliminary experiment using another cohort of rats, the food intake at 24 hours did not reach statistical significance (p=0.10; data not shown).

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Moreover, NPY and AgRP levels showed a decreasing trend with tofogliflozin, whereas in those of POMC did not significantly change ( figure 5D ).

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