Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis.

Primary tumors with BRAF mutations had significantly higher levels of methylation than BRAF wild-type tumors, while TP53 mutant tumors had lower levels of methylation than wild-type TP53 tumors, although these differences did not reach statistical significance in cell lines (Additional file 1 : Fig.

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