Interestingly, when we examined the yearly occurrence of HPV-positive OPSCC, we found that there was a trend for an increase over the 18 years of study, but it failed to reach statistical significance ( Fig 2 , S3 Table ).
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Understanding the impact of high-risk human papillomavirus on oropharyngeal squamous cell carcinomas in Taiwan: A retrospective cohort study.
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The sentences
In this study, we observed a transformation from cancer that is derived from only smoking, betel quid, and alcohol influence, to an increasing trend of HPV-positive cases.