While tocilizumab showed efficacy for GCA ( 49 ), it showed a trend of improvement but did not meet the study endpoint for Takayasu arteritis despite improvement in acute phase reactants ( 50 ).
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Inhibition of IL-6 in the LCWE Mouse Model of Kawasaki Disease Inhibits Acute Phase Reactant Serum Amyloid A but Fails to Attenuate Vasculitis.
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