Dietary Iron Intake in Excess of Requirements Impairs Intestinal Copper Absorption in Sprague Dawley Rat Dams, Causing Copper Deficiency in Suckling Pups.

Additionally, hepatic copper content trended lower in the 10× group (but did not reach statistical significance) and was significantly decreased in the 20× group (>3-fold lower than the 1× group), as compared to all others ( Figure 3 E).

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Although significance was not noted, erythrocyte SOD1 activity (percent inhibition) showed a decreasing trend in the 10× (~18%) and 20× (~23%) groups ( Figure 3 C).

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