Although a trend towards significance is still an indication of a failure to reach the specific threshold of p value set as p < 0.05, it is still necessary to step back and evaluate whether what has been detected is actually clinically relevant [ 45 ].
Although the overall subset analysis according with the type of vaccine reported that age was not a significant ( p > 0.05) modifying factor ( Figure 3 A), the results showed a trend toward significance ( p = 0.081) for mRNA-based vaccines ( Figure 3 B).
However, considering the mRNA-based vaccines, a trend toward significance ( p = 0.081) resulted for age.