Sirtuin 2 Dysregulates Autophagy in High-Fat-Exposed Immune-Tolerant Macrophages.

At 4 h post-LPS, while cells were able to clear autophagy (decreased yellow puncta), while at 24 h (tolerant cells), there was a strong trend towards the accumulation of LC3 in the vehicle and rapamycin-treated cells (Representative images: Supplemental Figure S2A and image quantification: Supplemental Figure S2B ), confirming dysregulation of autophagy in FFA-tolerant cells.

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