Enhanced Intestinal TGF-β/SMAD-Dependent Signaling in Simian Immunodeficiency Virus Infected Rhesus Macaques.

In contrast, a highly significant negative correlation was detected between the frequency of mucosal CD3 − CD20 − TGF-β + cells and CD4 + T cells in SIV infected animals ( r = −0.582, p < 0.0001, Figure 3 E). 3.4.

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We also detected increased presence of T cells (mean ± standard error, 0.71 ± 0.28 and 1.21 ± 0.44 for 0 and 14 dpi, respectively) and B cells (mean ± standard error, 0.77 ± 0.24 and 2.89 ± 1.42 for 0 and 14 dpi, respectively) positive for TGF-β 14 dpi, although this change did not reach statistical significance ( Figure 2 B,C).

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