Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased T_reg CD25 Expression and Reduced Frequency of Effector T_reg Subpopulation.

Frequency of T reg cells among CD4+ T cells defined using CD25 + alone, Foxp3 + alone, and CD25 + Foxp3 + was slightly elevated in RA patients compared to controls but did not reach statistical significance ( Figure 1 C).

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Indeed, in our study alone we observed an increasing trend of CD25 + Foxp3 + T reg cells in RA patients, but a decreasing trend in CD25 + CD127 −/low Foxp3 + T reg cells in RA patients ( Figure 1 ).

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