did not reach statistical significancep = 0.3489
In the absence of drugs, taking the complete set of data assembled in level L 2 , the number of different mutations that followed the same trajectory was 61 (98.4% of the total wave mutations) for HCV p200, and 38 (95.0% of the total) for HCV p100, but the tendency did not reach statistical significance ( p = 0.3489; proportion test).