Comparative Phenotypic and Functional Analyses of the Effects of IL-10 or TGF-β on Porcine Macrophages.

Interestingly, stimulation with TGF-β did not statistically significantly impair the ability of moMΦ to respond to these stimuli, although a clear trend was observed for IL-6 and IL-12 responses.

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Stimulation with 20 ng/mL of TGF-β did not statistically significantly impair the ability of moMΦ to release IL-1α, IL-1β, IL-6, IL-12, and TNF-α in response to either LPS or Pam2Cys lipopeptide, although a decreasing trend was observed for IL-6 and IL-12 in response to both stressors and for TNF-α in response to the TLR2 agonist ( Figure 5 ). 3.4.

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