IDO1-Targeted Therapy Does Not Control Disease Development in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia.

When analyzing the proliferation rate of leukemic cells by KI67 staining, a strong trend towards a higher percentage of proliferating cells was detected in the spleen of 1MT-treated mice compared to controls ( Figure 2 D; Supplementary Figure S2C for gating strategy), which might explain the loss of treatment efficacy over time.

also in 5,725 other papers