Aberrant Gut Microbiome Contributes to Intestinal Oxidative Stress, Barrier Dysfunction, Inflammation and Systemic Autoimmune Responses in MRL/lpr Mice.

Although decreased F/B ratio is not correlated with highly advanced disease activity in 18-week MRL/lpr mice, a lower F/B ratio at 6 weeks could be an important and highly significant contributing factor in promoting early disease onset.

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Even though NAC treatment resulted in a decreasing pattern for both ANA and anti-dsDNA levels in the serum, the differences did not reach statistical significance ( Figures 9A, B ).

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