Taurine Antagonizes Macrophages M1 Polarization by Mitophagy-Glycolysis Switch Blockage <i>via</i> Dragging SAM-PP2Ac Transmethylation.

Second, the expression level of Beclin1, a key protein regulating autophagosome formation, was consistent with that of LC3 II/I, however, a clear trend was not observed ( Figures 4H, I ) .

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The data showed that when M0 was polarized to M1 macrophages, the activities of glycolysis enzymes HK, PK, and LDH all showed an increasing trend, and the activity of PDH, the rate-limiting enzyme of the tricarboxylate (TCA) cycle, decreased markedly.

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