HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.

Stem Cell Reports · 2021 · PMC8072069 · PMID 33770497

Europe PMC DOI

hedged sentence

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

showed a trendp = 0.064so close (0.05 < p ≤ 0.1)

Of note, the DMSO treatment group, which reflects the effect of shHic1 induction alone at D20 on Atoh1-Enh-Prom-NLuc activity, showed a trend consistent with FACS-based results, yet did not achieve statistical significance (p = 0.064), which likely reflects the limitations of the luciferase-based assay, which quantifies bulk expression changes in unsorted organoid populations.

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