Association of Immune Related Adverse Events With Efficacy of Immune Checkpoint Inhibitors and Overall Survival in Cancers: A Systemic Review and Meta-analysis.

Front Oncol · 2021 · PMC8072154 · PMID 33912454

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a strong trendno p-value reported

Nevertheless, gastroenterological and lung irAEs showed a strong trend in improving PFS (HR 0.77, 95% CI 0.45–1.33, I 2 = 75.9% and HR 0.74, 95% CI 0.58–0.94, I 2 = 44.2%, respectively) and OS (HR 0.62, 95% CI 0.47, 0.81, I 2 = 49.7% and HR 0.59, 95% CI 0.34–1.04, I 2 = 30.4%, respectively) when compared to non-irAEs patients ( Table 3 and Figure 6 ).

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