Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.

GP also demonstrated evidence of suggestive causal association, with IVW estimates indicating increased odds of AD given higher GP levels (OR = 1.20, 95% CI = 1.05 to 1.38), and both HDL.D and XL.HDL.C demonstrated nominally significant associations in the negative direction (HDL.D: OR = 0.89, 95% CI = 0.80 to 0.99, XL.HDL.C: OR = 0.88, 95% CI = 0.79 to 0.99), though P values did not reach adjusted significance ( P > 0.009) ( Dataset S1 , Fig. 1 , and SI Appendix , Fig.

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