Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.

In contrast, the downregulated transcriptional signature of BAP1-deficient pre-B cells (Cluster V) showed a highly significant enrichment of GO-terms “cell cycle progression” and “DNA replication” ( Figure 4E , Supplemental Table S1D ), indicating the downregulation of genes involved in cell proliferation and cell cycle progression.

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The absolute numbers of B cells were also significantly reduced in the spleen of Bap1 fl/fl Cre mice and showed a trend toward reduction in the lymph nodes ( Figures 1C–E ).

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