Citric Acid Cycle Metabolites Predict Infarct Size in <i>Pigs</i> Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning.

When analyzed independently of the control group, pooled samples from the two groups receiving malonate showed a trend of having higher succinate concentrations than those receiving RIC alone (repeated measures ANOVA, p = 0.051 for interaction), and significantly reduced levels of fumarate (repeated measures ANOVA, p = 0.014 for interaction and p < 0.001 for group allocation) and malate (repeated measures ANOVA, p = 0.019 for group allocation).

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In addition, the enhancement in citrate levels observed in control animals was also attenuated in all treated groups ( Figure 6 D), whereas a marginally significant effect of group allocation was detected for lactate ( Figure 6 E).

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