Sex-specific DNA methylation differences in Alzheimer's disease pathology.

In sex-stratified analysis, although the methylation-Braak stage associations were highly significant (P-value female = 0.006, P-value male = 4.1 × 10 –5 ), they did not reach 5% FDR significance threshold (FDR female = 0.413, FDR male = 0.097).

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Notably, the TYROBP causal network reached the FDR significance threshold in females (FDR = 0.014) but was only nominally significant in males.

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