let-7e downregulation characterizes early phase colonic adenoma in APCMin/+ mice and human FAP subjects.

Except miR-29b , miR-22 , let-7e and miR-378 showed a strong trend towards down-regulation in the tumor tissue compared to the adjacent normal mucosa, with let-7e displaying a significative decrease expression, potentially supporting a tumor-suppressor role of these miRNAs ( Fig 5A ).

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Three out of seven microRNAs ( miR-7b , miR-22 and miR-199b ) display a slight trend to increase in ileum collected from APC Min/+ mice, while the others ( let-7e , miR-29b , miR-378 and miR-486 ) are significatively downregulated in cancerous lesions, thus indicating a closer association of these microRNAs to differentiation process rather than proliferation one ( Fig 4 ).

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