Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils.

administration of NAC during colitis induction, and although there was a trend toward reduced colitis in LTβR ΔN mice, especially regarding colon shortening due to fibrosis, the difference did not reach statistical significance ( Supp.

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While our data using NAC did not quite reach significance, and we did not observe an effect of Metformin in wildtype mice, lowering mitochondrial and NADPH-dependent ROS output and glucose availability with metformin effectively blocked the severe disease phenotype of LTβR ΔN mice.

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