Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways.

They were decreased to approximately 40 to 60% in the stomach, lung, and spleen of cKO mice compared with that in Ctrl mice, even though it did not reach statistical significance ( Fig. 5 , C – E ), and unaffected in the kidney ( Fig. 5 F ).

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We found TH-immunoreactive cells in the stomach and lung, where the TH protein showed a decreasing trend, but the DA levels were not decreased in cKO mice.

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