Role of IgA in the early-life establishment of the gut microbiota and immunity: Implications for constructing a healthy start.

Although no significant difference was apparent between the mammary IgA+ PCs of the two genotypes, the IgA levels in breast milk were higher in BALB/c mice. 4 Pups nursed by BALB/c mice, independent of their birth mothers, show higher fecal IgA levels and IgA+ bacterial proportions, which can also be transmitted through generations. 4 Furthermore, the colonic RORγ+ Treg level in mice nursed by Igha −/− BALB/c mice was higher than that in mice nursed by WT BALB/c mice, independent of their birth mother.

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