Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes.

In line with the results from the BrdU assays, all 3T3-L1 cells treated with 100 nM VaspinN showed significantly reduced p44/42 MAPK phosphorylation, which in part caused a reduction of PPARG and ADIPOQ expression 72 h after adipogenic induction, though these differences did not reach statistical significance.

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