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Diagnostic efficiency of hybrid imaging using PSMA ligands, PET/CT, PET/MRI and MRI in identifying malignant prostate lesions.

Ann Nucl Med · 2021 · PMC8079339 · PMID 33742373

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showed a trendno p-value reported
Summarizing the key findings of this study: (1) PSMA-PET/CT revealed superior diagnostic accuracy for delineating IPLs as compared to mpMRI; (2) no improvement in diagnostics of IPLs was shown by combined use of PSMA-PET/CT and mpMRI compared to PSMA-PET/CT alone; (3) no significant difference in diagnostic accuracy was observed between the hybrid method 68 Ga-PSMA-PET/MRI and separate techniques 18 F-PSMA-PET/CT and 68 Ga-PSMA-PET/CT, however, the hybrid method showed a trend to a higher diagnostic specificity; (4) superior diagnostic performance for 18 F-PSMA-PET/CT versus 68 Ga-PSMA-PET/CT was found for lesions localized in the base region; and (5) the volume of lesions and the grade of GS showed a positive correlation with diagnostic accuracy of PSMA-PET/CT and mpMRI.

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