Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications.

Front Neurosci · 2021 · PMC8079755 · PMID 33935624

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The amount of the CSF drained through this pathway is highly debatable, varying from negligible or little ( Marmarou et al., 1994 ; Gillooly et al., 2017 ) to quite significant (up to 50%) ( Boulton et al., 1999 ; Ma et al., 2017 ).

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