Large Cell Neuro-Endocrine Carcinoma of the Lung: Current Treatment Options and Potential Future Opportunities.

Front Oncol · 2021 · PMC8081906 · PMID 33937057

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a positive trendno p-value reported

Another prospective trial including forty patients with resected high-grade NEC of the lung (both LCNEC and SCLC) showed a positive trend on survival given by a post-operative chemotherapy with the combination of cisplatin and irinotecan for 4 cycles ( 68 ).

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a negative trendno p-value reported

Eichhorn and colleagues analyzed clinical and immunohistochemical predictors of survival after surgery in a retrospective cohort of 57 patients: a poorer prognosis was associated with advanced stage and advanced nodal involvement; a negative trend was also associated with the expression of neuroendocrine immunohistochemical markers: the expression of CgA, CD56 or both was a predictor for a significantly worse relapse-free survival and, not significantly, for a worse OS ( 59 ).

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