Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis.

BMC Neurosci · 2021 · PMC8082058 · PMID 33926378

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Moreover, low tidal volume ventilation increased the levels of glutamate ( p < 0.01), glycerol ( p < 0.05) and showed a trend towards higher lactate to pyruvate ratio ( p = 0.08) in cerebral microdialysate as well as higher levels of S-100B ( p < 0.05) in jugular venous plasma compared with medium–high tidal volume ventilation.

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