Machine learning workflows identify a microRNA signature of insulin transcription in human tissues.

In our analyses, both miR-204 and miR-30d were identified as highly significant (p < 2.349 × 10 −19 ) microRNAs and expressed at higher levels in adult human islets (8.4-cycles or 2 8.4 = 338-fold higher for miR-204 and 2.5-cycles or 2 2.5 = 5.7-fold higher for miR-30d; Table S2 ).

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A significant trend was observed for PDX1 , HNF4α , IGF2 , and GLUT1 , suggesting the added roles of microRNAs (M) and with LNAs (ML) in regulating their expression.

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