Antibody inhibition of both IFN-I and TNF signalling significantly downregulated CD86 to a much greater level compared to each individual treatment in MDDCs ( Fig 2C , right panel) and MDMs ( S2B Fig ) while CD80 was significantly downregulated in MDMs and showed a trend towards downregulation with the combined treatment in MDDCs.
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Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.
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The sentences
The correlation will obviously stay highly significant, but the p-value might change for scientific accuracy. 6) Another minor point, having the methods following the results, the S1A Fig. should be moved to be the last supplementary Figure as it first appears in the methods after all other supplementary Figures.