Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?

However, despite the reduced glucose disposal predominately caused by a decrease in non-oxidative glucose disposal, peripheral insulin sensitivity estimated by the ratio of the glucose metabolic clearance rate to the mean plasma concentration during a mixed meal test significantly increased after acute administration but the increase did not reach statistical significance after 14 days of treatment.

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