Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling.

Cortical histomorphometry could be performed in male Dmp1-Cre;Rosa Notch3 mice only due to the limited number of female mice available for study and revealed a substantial increase in cortical TRAP-positive osteoclasts and void or pore area (over 10-fold), although it did not reach statistical significance owing to variability in the results ( Table 5 ).

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