Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naïve patients with major depressive disorder.

Hum Brain Mapp · 2021 · PMC8090770 · PMID 33638263

Europe PMC DOI

hedged sentences

0.0250

closest p · 0.5× alpha

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boldest claim

The sentences

showed a trendp < .025actually significant

In addition, although we did not observe significant correlations between network FC change (baseline minus posttreatment) with ΔHRSD after FDR correction, three pairs of networks with FC change showed a trend negative correlation with ΔHRSD ( p < .025, uncorrected), including VN‐SMN, VN‐DAN, and VN‐FPN, a subset of those with decreased FC after treatment.

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marginally significantp = .050actually significant

NBS analysis showed a marginally significant cluster ( p = .050) consisting of 13 ROIs and 14 edges with negative correlation between FC change (baseline minus posttreatment) and ΔHRSD.

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