Associations of Genetic Factors, Educational Attainment, and Their Interaction With Kidney Function Outcomes.

Am J Epidemiol · 2021 · PMC8096480 · PMID 33089864

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0270

boldest claim

The sentences

highly significantP = 8.6 × 10 −9actually significant

The association of the WGS with baseline eGFR was modest but highly significant (B = −1.68 (standard error (SE), 0.29), R 2 adjusted = 0.010; P = 8.6 × 10 −9 ).

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nominally significantP = 0.027actually significant

borderline significantP = 0.062so close (0.05 < p ≤ 0.1)

Potential mediation was further supported by the finding that the overall interaction effect was only borderline significant after addition of these risk factors (model 6 versus model 5, P = 0.062 ( Table 3 )), although the interaction effect of the WGS with low versus high EA was not attenuated and remained nominally significant (model 6, B = −0.034 (SE, 0.015); P = 0.027) (Web Table 1).

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