Tumor Mutation Burden and Immune Invasion Characteristics in Triple Negative Breast Cancer: Genome High-Throughput Data Analysis.

Analysis of the Relationship Between High Mutation Target Gene and Drug Sensitivity in TNBC According to the analysis of the correlation between target gene and drug sensitivity, a significant correlation was found between the expression levels of the target gene FAT3 and clinical drug sensitivity ( Table 2 ), mainly related to drugs such as epothilone B, pelitrexol, asparaginase, methotrexate, and cladribine, and the correlation was of a negative trend; therefore, the lower the expression of FAT3, the more sensitive the cells were to these drugs.

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