Differential early subcortical involvement in genetic FTD within the GENFI cohort.

Thalamus C9orf72 expansion carriers showed significantly smaller thalamic regions in all stages, with the only exception being the ventromedial nucleus (which only became significant at CDR stage ≥ 1) and the ventral posterolateral nucleus, which did not quite reach statistical significance at CDR 0.5.

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The temporal pole was significantly smaller than controls in those scoring 0.5 (6%, p = 0.004), while the orbitofrontal, posterior cingulate, sensory and medial parietal cortex were significantly smaller in those scoring 0 (1–4%, p ≤ 0.028), but these differences did not reach statistical significance in those scoring 0.5 ( Supplementary Table 1 , Supplementary Fig. 2 ).

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