For MCPyV, a positive association of borderline significance was observed with increasing titer in gliomas overall ( p -value trend = 0.052) (Table 3 ).
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Prospective investigation of polyomavirus infection and the risk of adult glioma.
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The result for MCPyV differed according to glioma subtype (Supplemental Table S1 ): for GBM, ORs rose with increasing tertile (OR for tertile 3 vs seronegativity: 1.80 (95% CI 1.03–3.15) with a significant trend ( p -value trend = 0.048), whereas for nonGBM, the OR was significantly elevated only in the first tertile (OR for tertile 1 vs seronegativity: 2.11 (95% CI 1.06–4.19) and declined with increasing tertile (OR for tertile 3 vs seronegativity:1.29 (95% CI 0.59–2.81) with a nonsignificant trend ( p -value trend = 0.575).