Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.

Sci Rep · 2021 · PMC8102550 · PMID 33958660

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

a trend towards significancep ≤ 0.054so close (0.05 < p ≤ 0.1)

Luminescence readings in the lungs on Study Day 12 were significantly ( p ≤ 0.05, Dunnett’s multiple comparison test) lower in the group treated with mIL2-mIL12 and the TK-mIL2-mIL12 groups compared with the vehicle control and there was a trend towards significance for the group of mice treated with PEG-mIL12 ( p ≤ 0.054, Dunnett’s multiple comparison test) (Fig. 5 B).

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approaching significancep = 0.056so close (0.05 < p ≤ 0.1)

The difference in the level of IFN-γ was also approaching significance, p = 0.056.

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