Ghrelin-induced food intake did indeed differ among genotypes (Treatment: F (1,32) = 15.831, p < 0.001; Treatment × Genotype: F (2,32) = 2.562, p = 0.096), being significant in wild-type mice ( p = 0.005) although it did not reach statistical significance in heterozygous mice ( p = 0.072) ( Figure 4 C). 3.3.
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Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice.
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