A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis.

Brain · 2021 · PMC8105042 · PMID 33871026

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

highly significantP -value = 0not a probability at all

We identified and quantified 775 proteins in all pull-down samples ( n = 3–4 for each miRNA; Supplementary Table 6 ) and a gene ontology analysis (molecular function) revealed a highly significant enrichment of poly(A) RNA-binding and RNA-binding proteins (corrected P -value = 0 and 1.57 × 10 −115 , respectively; Supplementary Table 7 ).

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a strong trendP -value = 0.07so close (0.05 < p ≤ 0.1)

Nevertheless, a strong trend here (corrected P -value = 0.07) was also evident ( Fig. 3A ).

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