Does splenectomy significantly improve the prognosis of hepatocellular carcinoma patients with hypersplenism? A systematic review and meta-analysis.

The long-term mortality in the splenectomy group due to any reasons, such as HCC intrahepatic relapse or extrahepatic metastasis, and intractable gastrointestinal bleeding, was relatively lower than its counterpart, although the difference did not reach statistical significance (OR =0.78, 95% CI: 0.58–1.04, P=0.087).

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