Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis.

Cardiovasc Diabetol · 2021 · PMC8106208 · PMID 33962654

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did not reach statistical significanceno p-value reported

SGLT2i were associated with a lower risk of AF (RR 0.82, 95% CI 0.70–0.96), embolic stroke (RR 0.32, 95% CI 0.12–0.85), AF/AFL (RR 0.82, 95% CI 0.71–0.95), and VT (RR 0.73, 95% CI 0.53–0.99), while the risk reductions in AFL (RR 0.83, 95% CI 0.58–1.17) and cardiac arrest (RR 0.83, 95% CI 0.61–1.14) did not reach statistical significance.

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marginally significantno p-value reported

The low number of AFL events observed in the included trials in our meta-analysis might have contributed to a wide confidence interval, hence a marginally significant association.

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